Hydroxyacylglutathione hydrolase
| Hydroxyacylglutathione hydrolase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| EC number | 3.1.2.6 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
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In enzymology, a Hydroxyacylglutathione hydrolase (EC 3.1.2.6) is an enzyme that catalyzes the chemical reaction
- (R)-S-lactoylglutathione + water
glutathione + a 2-hydroxy carboxylate
Hence, this enzyme has two substrate, (R)-S-lactoylglutathione and water, and two products, glutathione and a 2-hydroxy carboxylate. With the common substrate methylglyoxal, the product is D-lactate.[1]
This enzyme belongs to the family of hydrolases, specifically the class of thioester lyases. This enzyme is commonly known as glyoxylase II. This enzyme participates in pyruvate metabolism.
References
- Ball JC, Vander Jagt DL (1979). "Purification of S-2-hydroxyacylglutathione hydrolase (glyoxalase II) from rat erythrocytes". Anal. Biochem. 98 (2): 472–7. doi:10.1016/0003-2697(79)90169-6. PMID 496013.